The Rohs Lab

Department of Quantitative and Computational Biology

University of Southern California

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About

Welcome to the Rohs Lab

About our Computational Biology and Bioinformatics research group

Main Focus

The main focus of our Computational Biology and Bioinformatics research group is the integration of two fields of research: genomics and structural biology.

Who Can Join

Professor Rohs can accept graduate students from the following Ph.D. Programs as primary thesis adviser: Computational Biology and Bioinformatics, Chemistry, Physics, and Computer Science.

Professor Rohs also advises graduate students from the Master's Program in Quantitative and Computational Biology and undergraduate students from the Bachelor's Program in Quantitative Biology.

Primary Goal

Our primary goal is to reveal yet unknown molecular mechanisms underlying gene regulation using bioinformatics analyses of high-throughput sequencing and DNA methylation data of whole genomes, integrated with experimental molecular biology approaches.

Structural biology and genomics are big fields, but there is little interaction between these two worlds.

Genomics thinks of entire genomes in terms of sequence, and structural biology thinks of 3-D structures at high resolution but limited size."

- Remo Rohs, Ph.D.

Selected Publications

T.P. Chiu, S. Rao, and R. Rohs*:
Physicochemical models of protein-DNA binding with standard and modified base pairs.
Proc. Natl. Acad. Sci. USA 120, e2205796120 (2023)
Supplementary Information

B.H. Cooper, T.P. Chiu, and R. Rohs*:
Top-Down-Crawl: a method for the ultra-rapid and motif-free alignment of sequences wiith associated binding metrics.
Bioinformatics 38, 5121-5123 (2022)
Supplementary Information

T.P. Chiu, J. Li, Y. Jiang, and R. Rohs*:
It is in the flanks: Conformational flexibility of transcription factor binding sites.
Biophys. J. 121, 3765-3767 (2022)